AHSP: a novel hemoglobin helper.
نویسنده
چکیده
Recently, the small protein alpha hemoglobin-stabilizing protein (AHSP) was identified and found to specifically bind alpha-globin, stabilize its structure, and limit the toxic effects of excess alpha-globin, which are manifest in the inherited blood disorder beta thalassemia. In this issue of the JCI, Yu, Weiss, and colleagues show that AHSP is also critical to the formation and stabilization of normal amounts of hemoglobin, even when alpha-globin is deficient, indicating unique and previously unidentified roles for this molecule.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 117 7 شماره
صفحات -
تاریخ انتشار 2007